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KMID : 0882420110810010130
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Korean Journal of Medicine
2011 Volume.81 No. 1 p.130 ~ p.134
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Late Adverse Reaction to Iodixanol (Visipaque®)
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Kim Cha-Young
Kim Hee-Jin
Kim Moon-Jin
Kang Yeo-Jin
Kim Hyun-Jung
Chang Se-Ho
Park Dong-Jun
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Abstract
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Late adverse reactions to iodinated contrast medium are defined as reactions occurring 1 hour to 1 week after contrast medium injection. The majority of late adverse reactions are cutaneous reactions, and include itching, maculopapular rash, urticaria, erythematous patches, and angioedema. We report a patient with an iodixanol (Visipaque®)-induced late adverse reaction. She was admitted for evaluation of nephrotic range proteinuria and edema. Abdomen and chest enhanced computed tomography was performed as a malignancy work-up. Sixteen hours after radiocontrast exposure, her entire body felt itchy. A maculopapular rash was first detected on her back and abdomen 24 hours after exposure, and spread over her entire body, including her face. Her skin lesions resolved completely in 5 days after administering steroid and antihistamine. We should consider late adverse reactions of iodinated contrast medium when we detect skin lesions late after radiocontrast use.
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KEYWORD
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Iodixanol, Hypersensitivity, Adverse reaction
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